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Citation for Study 16748

Citation title: "Non-coding RNA gene families in the genomes of anopheline mosquitoes".

Study name: "Non-coding RNA gene families in the genomes of anopheline mosquitoes".

This study is part of submission 16748 (Status: Published).

Citation

Dritsou V., Deligianni E., Dialynas E., Allen J., Poulakakis N., Louis C., Lawson D., & Topalis P. 2015. Non-coding RNA gene families in the genomes of anopheline mosquitoes. BMC Genomics, .

Authors

• Dritsou V.
• Deligianni E.
• Dialynas E.
• Allen J.
• Poulakakis N. (submitter)
• Louis C.
• Lawson D.
• Topalis P.

Abstract

Background Only a small fraction of the mosquito species of the genus Anopheles are able to transmit malaria, one of the biggest killer diseases of poverty, which is mostly prevalent in the tropics. This diversity has genetic, yet unknown, causes. In a further attempt to contribute to the elucidation of these variances, the international "Anopheles Genomes Cluster Consortium" project (a.k.a. "16 Anopheles genomes project") was established, aiming at a comprehensive genomic analysis of several anopheline species, most of which are malaria vectors. In the frame of the international consortium carrying out this project our team studied the genes encoding families of non-coding RNAs (ncRNAs), concentrating on four classes: microRNA (miRNA), ribosomal RNA (rRNA), small nuclear RNA (snRNA), and in particular small nucleolar RNA (snoRNA) and, finally, transfer RNA (tRNA). Results Our analysis was carried out using, exclusively, computational approaches, and evaluating both the primary NGS reads as well as the respective genome assemblies produced by the consortium and stored in VectorBase; moreover, the results of RNAseq surveys in cases in which these were available and meaningful were also accessed in order to obtain supplementary data, as were "pre-genomic era" sequence data stored in nucleic acid databases. The investigation included the identification and analysis, in most species studied, of ncRNA genes belonging to several families, as well as the analysis of the evolutionary relations of some of those genes in cross-comparisons to other members of the genus Anopheles. Conclusions Our study led to the identification of members of these gene families in the majority of twenty different anopheline taxa. A set of tools for the study of the evolution and molecular biology of important disease vectors has, thus, been obtained.

Keywords

Anopheles; genome evolution; microRNA; ncRNA; ribosomal genes; small nuclear RNA; small nucleolar RNA; tRNA; Whole Genome Sequencing

External links

About this resource

• Canonical resource URI: http://purl.org/phylo/treebase/phylows/study/TB2:S16748
• Other versions: Nexus NeXML
• Show BibTeX reference

  		@ARTICLE{TreeBASE2Ref23944,
  	 author = {Vicky   Dritsou and Elena  Deligianni and Emmanuel  Dialynas and James  Allen and Nikos  Poulakakis and Christos  Louis and Dan  Lawson and Pantelis  Topalis},
  	 title = {Non-coding RNA gene families in the genomes of anopheline mosquitoes},
  	 year = {2015},
  	 keywords = {Anopheles; genome evolution; microRNA; ncRNA; ribosomal genes; small nuclear RNA; small nucleolar RNA; tRNA; Whole Genome Sequencing},
  	 doi = {},
  	 url = {http://},
  	 pmid = {},
  	 journal = {BMC Genomics},
  	 volume = {},
  	 number = {},
  	 pages = {},
  	 abstract = {Background
  Only a small fraction of the mosquito species of the genus Anopheles are able to transmit malaria, one of the biggest killer diseases of poverty, which is mostly prevalent in the tropics. This diversity has genetic, yet unknown, causes. In a further attempt to contribute to the elucidation of these variances, the international "Anopheles Genomes Cluster Consortium" project (a.k.a. "16 Anopheles genomes project") was established, aiming at a comprehensive genomic analysis of several anopheline species, most of which are malaria vectors. In the frame of the international consortium carrying out this project our team studied the genes encoding families of non-coding RNAs (ncRNAs), concentrating on four classes: microRNA (miRNA), ribosomal RNA (rRNA), small nuclear RNA (snRNA), and in particular small nucleolar RNA (snoRNA) and, finally, transfer RNA (tRNA).
  Results
  Our analysis was carried out using, exclusively, computational approaches, and evaluating both the primary NGS reads as well as the respective genome assemblies produced by the consortium and stored in VectorBase; moreover, the results of RNAseq surveys in cases in which these were available and meaningful were also accessed in order to obtain supplementary data, as were "pre-genomic era" sequence data stored in nucleic acid databases. The investigation included the identification and analysis, in most species studied, of ncRNA genes belonging to several families, as well as the analysis of the evolutionary relations of some of those genes in cross-comparisons to other members of the genus Anopheles.
  Conclusions
  Our study led to the identification of members of these gene families in the majority of twenty different anopheline taxa. A set of tools for the study of the evolution and molecular biology of important disease vectors has, thus, been obtained.}
  }
  		

• Show RIS reference

  		TY  - JOUR
  ID  - 23944
  AU  - Dritsou,Vicky  
  AU  - Deligianni,Elena 
  AU  - Dialynas,Emmanuel 
  AU  - Allen,James 
  AU  - Poulakakis,Nikos 
  AU  - Louis,Christos 
  AU  - Lawson,Dan 
  AU  - Topalis,Pantelis 
  T1  - Non-coding RNA gene families in the genomes of anopheline mosquitoes
  PY  - 2015
  KW  - Anopheles; genome evolution; microRNA; ncRNA; ribosomal genes; small nuclear RNA; small nucleolar RNA; tRNA; Whole Genome Sequencing
  UR  - http://dx.doi.org/
  N2  - Background
  Only a small fraction of the mosquito species of the genus Anopheles are able to transmit malaria, one of the biggest killer diseases of poverty, which is mostly prevalent in the tropics. This diversity has genetic, yet unknown, causes. In a further attempt to contribute to the elucidation of these variances, the international "Anopheles Genomes Cluster Consortium" project (a.k.a. "16 Anopheles genomes project") was established, aiming at a comprehensive genomic analysis of several anopheline species, most of which are malaria vectors. In the frame of the international consortium carrying out this project our team studied the genes encoding families of non-coding RNAs (ncRNAs), concentrating on four classes: microRNA (miRNA), ribosomal RNA (rRNA), small nuclear RNA (snRNA), and in particular small nucleolar RNA (snoRNA) and, finally, transfer RNA (tRNA).
  Results
  Our analysis was carried out using, exclusively, computational approaches, and evaluating both the primary NGS reads as well as the respective genome assemblies produced by the consortium and stored in VectorBase; moreover, the results of RNAseq surveys in cases in which these were available and meaningful were also accessed in order to obtain supplementary data, as were "pre-genomic era" sequence data stored in nucleic acid databases. The investigation included the identification and analysis, in most species studied, of ncRNA genes belonging to several families, as well as the analysis of the evolutionary relations of some of those genes in cross-comparisons to other members of the genus Anopheles.
  Conclusions
  Our study led to the identification of members of these gene families in the majority of twenty different anopheline taxa. A set of tools for the study of the evolution and molecular biology of important disease vectors has, thus, been obtained.
  L3  - 
  JF  - BMC Genomics
  VL  - 
  IS  - 
  ER  -