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Citation for Study 19663

Citation title: "Recurrent evolution of host and vector association in bacteria of the Borrelia burgdorferi sensu lato species complex".

Study name: "Recurrent evolution of host and vector association in bacteria of the Borrelia burgdorferi sensu lato species complex".

This study is part of submission 19663 (Status: Published).

Citation

Becker N.S., Margos G., Blum H., Krebs S., Graf A., Lane R.S., Castillo-ramirez S., Sing A., & Fingerle V. 2016. Recurrent evolution of host and vector association in bacteria of the Borrelia burgdorferi sensu lato species complex. BMC Genomics, .

Authors

• Becker N.S. (submitter) 004989218074179
• Margos G.
• Blum H.
• Krebs S.
• Graf A.
• Lane R.S.
• Castillo-ramirez S.
• Sing A.
• Fingerle V.

Abstract

Background The Borrelia burgdorferi sensu lato (s.l.) species complex consists of tick-transmitted bacteria and currently comprises approximately 20 named and proposed genospecies some of which are known to cause Lyme Borreliosis. Species have been defined via genetic distances and ecological niches they occupy. Understanding the evolutionary relationship of species of the complex is fundamental to explaining patterns of speciation. This in turn forms a crucial basis to frame testable hypotheses concerning the underlying processes including host and vector adaptations. Results Illumina Technology was used to obtain genome-wide sequence data for 93 strains of 14 named genospecies of the B. burgdorferi species complex and genomic data already published for 18 additional strain (including one new species) was added. Phylogenetic reconstruction based on 114 orthologous single copy genes shows that the genospecies represent clearly distinguishable taxa with recent and still ongoing speciation events apparent in Europe and Asia. The position of Borrelia species in the phylogeny is consistent with host associations constituting a major driver for speciation. Interestingly, the data also demonstrate that vector associations are an additional driver for diversification in this tick-borne species complex. This is particularly obvious in B. bavariensis, a rodent adapted species that has diverged from the bird-associated B. garinii most likely in Asia. It now consists of two populations one of which most probably invaded Europe following adaptation to a new vector (Ixodes ricinus) and currently expands its distribution range. Conclusions The results imply that genotypes/species with novel properties regarding host or vector associations have evolved recurrently during the history of the species complex and may emerge at any time. We suggest that the finding of vector associations as a driver for diversification may be a general pattern for tick-borne pathogens. The core genome analysis presented here provides an important source for investigations of the underlying mechanisms of speciation in tick-borne pathogens.

Keywords

Borrelia burgdorferi sensu lato, evolution, population genomics, host association, vector adaptation, Lyme disease

External links

About this resource

• Canonical resource URI: http://purl.org/phylo/treebase/phylows/study/TB2:S19663
• Other versions: Nexus NeXML
• Show BibTeX reference

  		@ARTICLE{TreeBASE2Ref26172,
  	 author = {No?mie S. Becker and Gabriele  Margos and Helmut  Blum and Stefan  Krebs and Alexander  Graf and Robert S. Lane and Santiago  Castillo-Ramirez and Andreas  Sing and Volker  Fingerle},
  	 title = {Recurrent evolution of host and vector association in bacteria of the Borrelia burgdorferi sensu lato species complex},
  	 year = {2016},
  	 keywords = {Borrelia burgdorferi sensu lato, evolution, population genomics, host association, vector adaptation, Lyme disease},
  	 doi = {},
  	 url = {http://},
  	 pmid = {},
  	 journal = {BMC Genomics},
  	 volume = {},
  	 number = {},
  	 pages = {},
  	 abstract = {Background
  The Borrelia burgdorferi sensu lato (s.l.) species complex consists of tick-transmitted bacteria and currently comprises approximately 20 named and proposed genospecies some of which are known to cause Lyme Borreliosis. Species have been defined via genetic distances and ecological niches they occupy. Understanding the evolutionary relationship of species of the complex is fundamental to explaining patterns of speciation. This in turn forms a crucial basis to frame testable hypotheses concerning the underlying processes including host and vector adaptations. 
  Results
  Illumina Technology was used to obtain genome-wide sequence data for 93 strains of 14 named genospecies of the B. burgdorferi species complex and genomic data already published for 18 additional strain (including one new species) was added. Phylogenetic reconstruction based on 114 orthologous single copy genes shows that the genospecies represent clearly distinguishable taxa with recent and still ongoing speciation events apparent in Europe and Asia. The position of Borrelia species in the phylogeny is consistent with host associations constituting a major driver for speciation. Interestingly, the data also demonstrate that vector associations are an additional driver for diversification in this tick-borne species complex. This is particularly obvious in B. bavariensis, a rodent adapted species that has diverged from the bird-associated B. garinii most likely in Asia. It now consists of two populations one of which most probably invaded Europe following adaptation to a new vector (Ixodes ricinus) and currently expands its distribution range. 
  Conclusions
  The results imply that genotypes/species with novel properties regarding host or vector associations have evolved recurrently during the history of the species complex and may emerge at any time. We suggest that the finding of vector associations as a driver for diversification may be a general pattern for tick-borne pathogens. The core genome analysis presented here provides an important source for investigations of the underlying mechanisms of speciation in tick-borne pathogens.     }
  }
  		

• Show RIS reference

  		TY  - JOUR
  ID  - 26172
  AU  - Becker,No?mie S.
  AU  - Margos,Gabriele 
  AU  - Blum,Helmut 
  AU  - Krebs,Stefan 
  AU  - Graf,Alexander 
  AU  - Lane,Robert S.
  AU  - Castillo-Ramirez,Santiago 
  AU  - Sing,Andreas 
  AU  - Fingerle,Volker 
  T1  - Recurrent evolution of host and vector association in bacteria of the Borrelia burgdorferi sensu lato species complex
  PY  - 2016
  KW  - Borrelia burgdorferi sensu lato
  KW  - evolution
  KW  - population genomics
  KW  - host association
  KW  - vector adaptation
  KW  - Lyme disease
  UR  - http://dx.doi.org/
  N2  - Background
  The Borrelia burgdorferi sensu lato (s.l.) species complex consists of tick-transmitted bacteria and currently comprises approximately 20 named and proposed genospecies some of which are known to cause Lyme Borreliosis. Species have been defined via genetic distances and ecological niches they occupy. Understanding the evolutionary relationship of species of the complex is fundamental to explaining patterns of speciation. This in turn forms a crucial basis to frame testable hypotheses concerning the underlying processes including host and vector adaptations. 
  Results
  Illumina Technology was used to obtain genome-wide sequence data for 93 strains of 14 named genospecies of the B. burgdorferi species complex and genomic data already published for 18 additional strain (including one new species) was added. Phylogenetic reconstruction based on 114 orthologous single copy genes shows that the genospecies represent clearly distinguishable taxa with recent and still ongoing speciation events apparent in Europe and Asia. The position of Borrelia species in the phylogeny is consistent with host associations constituting a major driver for speciation. Interestingly, the data also demonstrate that vector associations are an additional driver for diversification in this tick-borne species complex. This is particularly obvious in B. bavariensis, a rodent adapted species that has diverged from the bird-associated B. garinii most likely in Asia. It now consists of two populations one of which most probably invaded Europe following adaptation to a new vector (Ixodes ricinus) and currently expands its distribution range. 
  Conclusions
  The results imply that genotypes/species with novel properties regarding host or vector associations have evolved recurrently during the history of the species complex and may emerge at any time. We suggest that the finding of vector associations as a driver for diversification may be a general pattern for tick-borne pathogens. The core genome analysis presented here provides an important source for investigations of the underlying mechanisms of speciation in tick-borne pathogens.     
  L3  - 
  JF  - BMC Genomics
  VL  - 
  IS  - 
  ER  -