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Citation for Study 20413

Citation title: "ChMob2 binds to ChCbk1 and promotes virulence and conidiation of the fungal pathogen Colletotrichum higginsianum".

Study name: "ChMob2 binds to ChCbk1 and promotes virulence and conidiation of the fungal pathogen Colletotrichum higginsianum".

This study is part of submission 20413 (Status: Published).

Citation

Schmidpeter J., Dahl M., Hofmann J., & Koch C. 2017. ChMob2 binds to ChCbk1 and promotes virulence and conidiation of the fungal pathogen Colletotrichum higginsianum. BMC Microbiology, .

Authors

• Schmidpeter J. (submitter) 017623984129
• Dahl M.
• Hofmann J.
• Koch C.

Abstract

Background Mob family proteins are conserved between animals, plants and fungi and are essential for the activation of NDR kinases that control crucial cellular processes like cytokinesis, proliferation and morphology. Results We identified a hypomorphic allele of ChMOB2 in a random insertional mutant (vir-88) of the hemibiotrophic ascomycete fungus Colletotrichum higginsianum. The mutant is impaired in conidiation, host penetration and virulence on Arabidopsis thaliana. ChMob2 binds to and co-localizes with the NDR/LATS kinase homolog ChCbk1. Mutants in the two potential ChCbk1 downstream targets ChSSD1 and ChACE2 show defects in pathogenicity. The genome of C. higginsianum encodes two more Mob proteins. While we could not detect any effect on pathogenicity in ΔChmob3 mutants, ChMob1 is involved in conidiation, septae formation and virulence. Conclusion This study shows that ChMob2 binds to the conserved NDR/LATS Kinase ChCbk1 and plays an important role in pathogenicity of Colletotrichum higginsianum on Arabidopsis thaliana.

Keywords

Phytopathogenic ascomycete fungus, ATMT, Colletotrichum higginsianum, conidiation, NDR Kinase Cbk1, Mob1, Mob2, Mob3, Ace2, Ssd1, Cts1

External links

About this resource

• Canonical resource URI: http://purl.org/phylo/treebase/phylows/study/TB2:S20413
• Other versions: Nexus NeXML
• Show BibTeX reference

  		@ARTICLE{TreeBASE2Ref26743,
  	 author = {Johannes  Schmidpeter and Marlis  Dahl and Joerg  Hofmann and Christian  Koch},
  	 title = {ChMob2 binds to ChCbk1 and promotes virulence and conidiation of the fungal pathogen Colletotrichum higginsianum},
  	 year = {2017},
  	 keywords = {Phytopathogenic ascomycete fungus, ATMT, Colletotrichum higginsianum, conidiation, NDR Kinase Cbk1, Mob1, Mob2, Mob3, Ace2, Ssd1, Cts1},
  	 doi = {},
  	 url = {http://},
  	 pmid = {},
  	 journal = {BMC Microbiology},
  	 volume = {},
  	 number = {},
  	 pages = {},
  	 abstract = {Background
  Mob family proteins are conserved between animals, plants and fungi and are essential for the activation of NDR kinases that control crucial cellular processes like cytokinesis, proliferation and morphology. 
  Results
  We identified a hypomorphic allele of ChMOB2 in a random insertional mutant (vir-88) of the hemibiotrophic ascomycete fungus Colletotrichum higginsianum. The mutant is impaired in conidiation, host penetration and virulence on Arabidopsis thaliana. ChMob2 binds to and co-localizes with the NDR/LATS kinase homolog ChCbk1. Mutants in the two potential ChCbk1 downstream targets ChSSD1 and ChACE2 show defects in pathogenicity. The genome of C. higginsianum encodes two more Mob proteins. While we could not detect any effect on pathogenicity in ΔChmob3 mutants, ChMob1 is involved in conidiation, septae formation and virulence.
  Conclusion
  This study shows that ChMob2 binds to the conserved NDR/LATS Kinase ChCbk1 and plays an important role in pathogenicity of Colletotrichum higginsianum on Arabidopsis thaliana.
  }
  }
  		

• Show RIS reference

  		TY  - JOUR
  ID  - 26743
  AU  - Schmidpeter,Johannes 
  AU  - Dahl,Marlis 
  AU  - Hofmann,Joerg 
  AU  - Koch,Christian 
  T1  - ChMob2 binds to ChCbk1 and promotes virulence and conidiation of the fungal pathogen Colletotrichum higginsianum
  PY  - 2017
  KW  - Phytopathogenic ascomycete fungus
  KW  - ATMT
  KW  - Colletotrichum higginsianum
  KW  - conidiation
  KW  - NDR Kinase Cbk1
  KW  - Mob1
  KW  - Mob2
  KW  - Mob3
  KW  - Ace2
  KW  - Ssd1
  KW  - Cts1
  UR  - http://dx.doi.org/
  N2  - Background
  Mob family proteins are conserved between animals, plants and fungi and are essential for the activation of NDR kinases that control crucial cellular processes like cytokinesis, proliferation and morphology. 
  Results
  We identified a hypomorphic allele of ChMOB2 in a random insertional mutant (vir-88) of the hemibiotrophic ascomycete fungus Colletotrichum higginsianum. The mutant is impaired in conidiation, host penetration and virulence on Arabidopsis thaliana. ChMob2 binds to and co-localizes with the NDR/LATS kinase homolog ChCbk1. Mutants in the two potential ChCbk1 downstream targets ChSSD1 and ChACE2 show defects in pathogenicity. The genome of C. higginsianum encodes two more Mob proteins. While we could not detect any effect on pathogenicity in ΔChmob3 mutants, ChMob1 is involved in conidiation, septae formation and virulence.
  Conclusion
  This study shows that ChMob2 binds to the conserved NDR/LATS Kinase ChCbk1 and plays an important role in pathogenicity of Colletotrichum higginsianum on Arabidopsis thaliana.
  
  L3  - 
  JF  - BMC Microbiology
  VL  - 
  IS  - 
  ER  -