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Citation for Study 20933

Citation title: "A maternal-effect selfish genetic element in Caenorhabditis elegans".

Study name: "A maternal-effect selfish genetic element in Caenorhabditis elegans".

This study is part of submission 20933 (Status: Published).

Citation

Ben-david E., Burga A., & Kruglyak L. 2017. A maternal-effect selfish genetic element in Caenorhabditis elegans. Science, .

Authors

Ben-david E.
Burga A.
Kruglyak L.

Abstract

Selfish genetic elements spread in natural populations and have an important role in genome evolution. We discovered a selfish element causing embryonic lethality in crosses between wild strains of the nematode Caenorhabditis elegans. The element is made up of sup-35, a maternal-effect toxin that kills developing embryos, and pha-1, its zygotically expressed antidote. pha-1 has long been considered essential for pharynx development on the basis of its mutant phenotype, but this phenotype arises from a loss of suppression of sup-35 toxicity. Inactive copies of the sup-35/pha-1 element show high sequence divergence from active copies, and phylogenetic reconstruction suggests that they represent ancestral stages in the evolution of the element. Our results suggest that other essential genes identified by genetic screens may turn out to be components of selfish elements.

About this resource

Canonical resource URI: http://purl.org/phylo/treebase/phylows/study/TB2:S20933
Other versions: Nexus NeXML

Show BibTeX reference

		@ARTICLE{TreeBASE2Ref27161,
	 author = {Eyal  Ben-David and Alejandro  Burga and Leonid  Kruglyak},
	 title = {A maternal-effect selfish genetic element in Caenorhabditis elegans},
	 year = {2017},
	 keywords = {},
	 doi = {},
	 url = {},
	 pmid = {},
	 journal = {Science},
	 volume = {},
	 number = {},
	 pages = {},
	 abstract = {Selfish genetic elements spread in natural populations and have an important role in genome evolution. We discovered a selfish element causing embryonic lethality in crosses between wild strains of the nematode Caenorhabditis elegans. The element is made up of sup-35, a maternal-effect toxin that kills developing embryos, and pha-1, its zygotically expressed antidote. pha-1 has long been considered essential for pharynx development on the basis of its mutant phenotype, but this phenotype arises from a loss of suppression of sup-35 toxicity. Inactive copies of the sup-35/pha-1 element show high sequence divergence from active copies, and phylogenetic reconstruction suggests that they represent ancestral stages in the evolution of the element. Our results suggest that other essential genes identified by genetic screens may turn out to be components of selfish elements.}
}

Show RIS reference

		TY  - JOUR
ID  - 27161
AU  - Ben-David,Eyal 
AU  - Burga,Alejandro 
AU  - Kruglyak,Leonid 
T1  - A maternal-effect selfish genetic element in Caenorhabditis elegans
PY  - 2017
KW  - 
UR  - 
N2  - Selfish genetic elements spread in natural populations and have an important role in genome evolution. We discovered a selfish element causing embryonic lethality in crosses between wild strains of the nematode Caenorhabditis elegans. The element is made up of sup-35, a maternal-effect toxin that kills developing embryos, and pha-1, its zygotically expressed antidote. pha-1 has long been considered essential for pharynx development on the basis of its mutant phenotype, but this phenotype arises from a loss of suppression of sup-35 toxicity. Inactive copies of the sup-35/pha-1 element show high sequence divergence from active copies, and phylogenetic reconstruction suggests that they represent ancestral stages in the evolution of the element. Our results suggest that other essential genes identified by genetic screens may turn out to be components of selfish elements.
L3  - 
JF  - Science
VL  - 
IS  - 
ER  -