@ARTICLE{TreeBASE2Ref24163, author = {Tomoki Yoshikawa and Masayuki Shimojima and Shuetsu Fukushi and Hideki Tani and Aiko Fukuma and Satoshi Taniguchi and Harpal Singh and Yuto Suda and Komei Shirabe and Shoichi Toda and Yukie Shimazu and Taro Nomachi and Mutsuyo Gokuden and Toshiharu Morimitsu and Katsuyuki Ando and Akira Yoshikawa and Miki Kan and Marina Uramoto and Hideo Osako and Kouji Kida and Hirokazu Takimoto and Hiroaki Kitamoto and Fumio Terasoma and Akiko Honda and Ken Maeda and Toru Takahashi and Takuya Yamagishi and Kazunori Oishi and Shigeru Morikawa and Masayuki Saijo}, title = {Phylogenetic and geographic relationships of severe fever with thrombocytopenia syndrome virus}, year = {2015}, keywords = {Severe fever with thrombocytopenia syndrome; SFTS, SFTS virus; tick borne virus infection; bunyavirus}, doi = {}, url = {http://}, pmid = {257627}, journal = {The Journal of Infectious Diseases}, volume = {}, number = {}, pages = {}, abstract = {Background. Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne acute infectious disease caused by the SFTS virus (SFTSV). SFTS has been reported in China, South Korea, and Japan as a novel Bunyavirus. Although several molecular epidemiology and phylogenetic studies have been performed, the information obtained was limited, since the analyses included no or only a small number of SFTSV strains from Japan. Methods. The nucleotide sequences of 75 SFTSV strains in Japan were newly determined directly from the patients' sera. In addition, the sequences of seven strains isolated in vitro were determined and compared with those in the patients' sera. More than 90 strains that were identified in China, one strain in South Korea, and 50 strains in Japan were phylogenetically analyzed. Results. The viruses were clustered into two clades, which were consistent with the geographic distribution. Three strains identified in Japan were clustered in the Chinese clade, and four strains identified in China and 26 in South Korea were clustered in the Japanese clade. Conclusions. Two clades of SFTSV may have evolved separately over time. On rare occasions, the viruses were transmitted overseas to the region in which viruses of the other clade were prevalent.} }

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